Anders Blomberg completed his PhD in Microbiology in 1988 with a thesis entitled "Osmoregulation and Osmotolerance in Yeast". He holds since 2002 a position as professor in Functional Genomics at the University of Gothenburg. He was during 2001 - 2008 director of the Swedish national Research School in Genomics and Bioinformatics. Blomberg is deputy coordinator of the Centre for Marine Evolutionary Biology (CEMEB) at the university. He has published 83 primary publications in international journals and 14 reviews/book chapters. Blomberg runs a research group of roughly 10 members currently composed of 2 PhD students (has earlier supervised in total 10 PhD students), 7 post-docs/researchers and several master’s students.
Research team (2016-03-18): Ulrika Lind (researcher), Magnus Alm Rosenblad (researcher), Mats Töpel (researcher), Luciano Fernandez-Ricaud (researcher), Peter Dahl (researcher), Tomas Larsson (post-doc), Valeria Wallace (post-doc), Martin Zackrisson (PhD student), Anna Abramova (PhD student), Emil Karlsson (master’s student), Sabiha Amir (master’s student), Esteban Fernandez Parada (master’s student), Tarek Elhasi (master’s student), Merce Montoliu (master’s student).
Link to the web-site for the group (under construction).
Publication Google Scholar: scholar.google.se/citations
The research in Blomberg’s group runs along four main paths:
i) Osmoregulatory mechanisms in eukaryotes
Blomberg has over the years applied various genome-wide technologies, e.g. proteomics and phenomics, on the yeast Sacchaomyces cerevisiae for the characterization of its salinity stress response and osmoregulatory mechanisms. This has resulted in identification of genes involved in the osmolyte glycerol’s production and accumulation (GPD1, GPP2), the importance of N-terminal acetylations on specific stress-proteins (TFS1) and a molecular understanding of the salt stress induced dihydroxyacetone toxicity (DAK1). We have also initiated studies on genes of importance in osmoregulation in the barnacle Balanus improvisus, e.g. the primary transporter Na+/K+ ATPase, aquaporins and proline biosynthetic components. Salinity controlled genes in the low-salt response in B. improvisus are examined by RNA-sequencing and heterologous expression in yeast for functional characterisation. We also conduct population genomics and phenomics studies on the highly salt-tolerant marine fungi/yeast Debaryomyces hansenii.
Lind, U., Alm Rosenblad, M., Wrange, A.-L., Sundell, K.S., Jonsson, P.R., André, C., Havenhand, J., Blomberg, A.
Molecular characterization of the α-subunit of Na+/K+ ATPase from the euryhaline barnacle Balanus improvisus reveals multiple genes and differential expression of alternative splice variants
PLoS One (2013) 8:e77069
Logg, K., Warringer, J., Hashemi, S. H., Käll, M., and Blomberg, A.
The sodium pump Ena1p provides mechanistic insight into the salt sensitivity of vacuolar sorting mutants
BBA –Molecular Cell Research (2008) 1783:974-84
ii) Phenomics - large-scale phenotypic profiling
Phenotypic profiling of genetically defined strains, e.g. gene-deletions and fully sequenced natural isolates, is essential to characterize the relation between genotype and phenotype. We are developing methodology for large-scale high-resolution phenotyping of microbial growth dynamics. Our systems allows for analysis of up to 100,000 thousand mutants/strains per week based on automated cultivation and recording coupled with robust statistics and feature extraction. In various collaborations we have also develop and characterised genetically engineered strains. The phenotypic data can be accessed on our phenomics-database PROPHECY.
Liti, L., Carter, D., Moses, Warringer, J, A., Parts., L., James, S.A., Robert, P.D., Roberts, I.N., Burt, A., Koufopanou, V., Tsai, I.J., Bergman, B., Bensasson, D., O’Kelly, M.J.T., von Oudenaarden, A., Barton, D.B.H., Bailes, E.,Nguyen, A.N., Jones, M., Qual, M.A., Goodhead, I., Sims, S., Smith, F., Blomberg, A., Durbin, R., and Louis, E.J.
Population genomics of domestic and wild yeasts.
Nature (2009) 458:337
Warringer J, Zörgö E, Cubillos FA, Zia A, Gjuvsland A, Simpson JT, Forsmark A, Durbin R, Omholt SW, Louis EJ, Liti G, Moses A, Blomberg A.
Trait variation in yeast is defined by population history
PLoS Genetics (2011) 7:e1002111
iii) Marine biotechnology
Blomberg is involved in several projects in marine biotechnology: i) Studies of antifouling with an emphasis of molecular studies of the barnacle Balanus improvisus that is the main boifouling organism on ship-hulls in north-European waters. These investigations have resulted in identification and characterization of five octopamine receptors that are involved in the sensing of the antifouling substance medetomidine. ii) Proteomics analysis of components in slime in the hagfish Myxine glutinosa for applications in biomedicine. iii) Analysis of barnacle cement proteins for the development of underwater glue. iv) Biodiscovery of new marine substances and the characterisation by high-throughput chemical genetic screens of their mode-of-action.
Ulrika Lind, Magnus Alm Rosenblad, Linda Hasselberg Frank, Susanna Falkbring, Lars Brive, Jonne M Laurila, Katariina Pohjanoksa, Anne Vuorenpää; Jyrki P. Kukkonen Lina Gunnarsson, Mika Scheinin, Lena G.E. Mårtensson Lindblad and Anders Blomberg.
Octopamine receptors from the barnacle Balanus improvisus are activated by the α2-adrenoceptor agonist medetomidine.
Molecular Pharmacology (2010) 78:237
iv) Genome sequencing of marine key-species on the Swedish west-coast
The group leads 8 genome sequencing projects for marine organisms to be found along the Swedish west-coast. This activity is part of CEMEB (the subproject IMAGO) with the aim to develop a number of marine key-organisms in ecology and marine biotechnology into powerful genetic model systems.
- Bioinformatics and functional genomics, 15hec (BIO210)
- Advanced functional genomics, 15hec (BIO406)
- Drug development, 7.5hec (BIO523)
- Cellbiology, genetics and applications of molecular biology methods, 7.5hec (MAR104)
- Head of course: Bioinformatics and functional genomics, 15hec (BIO210) (2000 – present)
- Head of course: Advanced functional genomics, 15hec (BIO406) (2012- present)
- Director of master’s programme in Genomics and systems biology (2012 – present)
COMMISSION OF TRUST
- Vice director of the Centre for Marine Evolutionary Biology (Univ. of Gothenburg)(2010 - present)
- Member of the scientific advisory board for the yeast database Saccharomyces Genome Database (SGD) at Stanford University, USA (2006 - present)
- Editorial board for FEMS Yeast Research (2007 - present)
- Editorial board of Microbial Cell (2013 - present)
- Member of the organisation committee of the international Yeast Genetics meeting (2008- 2013)
- Member of the evaluation committee for Swedish Research Council (2011 and 2012)
- Chairperson for the Evaluation of higher Biology Education in Sweden (HSV/UKÄ) (2012)
- Chairperson for evaluation by European Science Foundation for the European Space Agency programme (2009)
- Director of the Swedish national Research School in Genomics and Bioinformatics (2002 – 2008)